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Bulk Reagent Dispenser Trends 2012

Date Published: November 2012
Format: PDF
Pages: 59
Publisher: HTStec
Product Code: jc09091313
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Bulk Reagent Dispenser Trends 2012

• This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on bulk reagent dispensers (BRDs) carried out in October 2012.
• The study was initiated by HTStec as part of its ongoing tracking of life science technologies and to update the previous report (March 2010). The main objectives were to comprehensively document current use of and experience with bulk reagent dispensers (e.g. Thermo Scientific Multidrop). The survey also investigated dispensing problems, instrument reliability, experience of BRD service and maintenance, influences on purchasing decisions, and interest in alternative purchasing scenarios. An additional objective was to estimate the current market size for BRD instruments and BRD-related consumables.
• The survey looked at the following aspects of BRDs as practiced to date (2012) and in a few cases as predicted for the future (2015): current use of BRDs; makeup of vendor BRDs in respondent’s labs and which vendor’s BRDs are most used; how many BRDs are in respondent’s labs; % of BRD dispensing done in plate/racked tube formats; BRD dispensing volume ranges most used in various formats and final assay volume targeted; batch sizes processed and throughput requirements in various formats; types of liquids dispensed; main purpose and application areas of BRD dispensing; reliability of existing commercial BRDs; level of satisfaction with BRDs; frequency of occurrence of technical issues; main problems encountered day-to-day with BRDs which can be rectified by respondents or necessitate a service callout; how respondents currently manage the service and maintenance of their BRDs; frequency of service calls needed to support BRD functioning; influence of brand on the purchasing selection of a BRD; preferred brand of BRD and purchasing of another brand of BRD recently; influence of factors on a BRD purchasing decision; BRD purchasing frequency; paying a price premium for an improved BRD; whether respondents have experienced any trends related to the purchasing of new BRDs and related consumables; openness to consider alternative purchasing scenarios; interest in other purchasing strategies relative to the outright BRD purchase model; BRD capex budget allocation; future purchasing probability; vendor’s BRD system most likely to purchase; breakdown of total liquid handling capex budget; BRD-related consumables budget; and any unmet needs in BRD dispensing today.
• The main questionnaire consisted of 28 multi-choice questions and 3 open-ended questions. In addition, there were 6 questions related solely to the administration of survey.
• The survey collected 127 validated responses, of these 76% provided comprehensive input.
• Survey responses were geographically split: 60% North America; 21% Europe; 13% Asia (excluding Japan); 5% Japan; and 1% Rest of World.
• Respondents came from 58 University/Research Institute/Not-for-Profit Facilities; 29 Pharma; 16 Biotechs; 6 Medical Schools/Hospitals/Clinics; 6 Others; 4 CROs; 3 Academic Screening Centers; 3 Agrochemical/Agri-Biotech/Plant Genomics Companies; and 3 Diagnostics Companies.
• Most survey respondents had a senior job role or position which was in descending order: 35 research scientists; 24 senior scientists/researchers; 12 principal investigators; 12 post-docs; 9 professors/ assistant professors; 8 directors; 7 section/group leaders; 7 graduates/PhD students; 6 lab managers; 5 others; and 2 department heads.
• Respondents represented labs with the following main activities: 48 basic research; 19 assay development; 15 primary screening (HTS); 11 applied/other industry research; 11 with a combination of drug discovery roles; 9 other; 4 therapeutic areas (target ID/validation); 3 leads-to-candidate (ADME tox/preclinical research); 3 secondary screening; 2 hits-to-leads (lead optimization); and 2 compound management.
• Survey results were expressed as an average of all survey respondents. In addition, were appropriate the data was reanalyzed after sub-division into the following 5 survey groups: 1) Pharma; 2) Applied Research; 3) Academic Research; 4) Europe; and 5) North America.
• The current level of use of BRDs by most survey respondents was frequent.
• BRDs from Thermo Scientific were the most prevalent in respondent’s labs today.
• BRDs from Thermo Scientific were those used to the greatest extent in respondent’s labs today.
• The median number of BRDs per lab was 2, with a median functional lifetime of 5 years.
• Most BRD dispensing today (2012) was still done mainly into 96-well plates.
• 5μL-50μL was the dispensing volume range most used in 96-well plates.
• 25μL-100μL was the final assay volume range most targeted using a BRD in 96-well plates.
• A median batch size of 5-10 96-well plates were typically processed when BRD dispensing.
• A median throughput of 5-10 96-well plates/8h day were typically processed when BRD dispensing.

Executive Summary .................................. 2
Table of Contents ..................................... 4
Survey Methodology ................................. 5
Respondent’s Organisational Origin and Response to Survey....................... 6
Respondent’s Company or Organisational Origin ......................... 7
Respondent’s Geographic Origin .............................. 8
Respondent’s Job Role .................................. 9
Respondent’s Main Area of Activity ............................ 10
Current Level of Use of BRDs .............................. 11
BRDs in Survey Respondent’s Labs Today........................... 12
BRDs Respondents Make Greatest Use of Today ......................... 13
Number of BRDs per Lab & Average Functional Lifetime (1) ....................... 14
Number of BRDs per Lab & Average Functional Lifetime (2) ....................... 15
% Bulk Dispensing Done in Plate/Racked Tube Formats Today (2012) ................... 16
Most Used BRD Volume Ranges Associated With Formats Dispensed ..................... 17
Final Assay Volume Ranges Targeted Associated With Formats Dispensed ................ 18
Summary of Survey Findings (1) ............................. 19
Typical Batch Sizes of Plates or Racked Tubes Used When Bulk Dispensing ................... 20
Typical Throughput Achieved When Bulk Dispensing ......................... 21
Bulk Dispensing Done Using Various Liquid Types ......................... 22
Main Purpose Respondents BRDs are Used for ........................... 23
Main Application Areas Where BRDs are Used ............................ 24
BRD Reliability - % Fully Operational .............................. 25
Satisfaction with Existing BRDs............................... 26
Main BRD Problems That Can be Rectified by Respondents ........................ 27
Frequency of Occurrence of Specific Technical Problems with BRDs .................. 29
Main BRD Problems That Have Necessitated a Service Callout .................... 30
Managing Service & Maintenance of BRDs .......................... 31
Frequency of Service Calls Needed to Support BRD Function ...................... 32
Influence of Brand on BRD Purchasing Selection......................... 33
Preferred Brand of BRD ................................... 34
Respondents Who Have Purchased an Alternative Brand of BRD Recently .................. 35
Respondents Who Have Changed BRD Brands Recently ...................... 36
Influence of Criteria on Purchasing Decision to Change BRD Brand ................... 37
Frequency of Purchasing New BRDs & Need to Replace Old BRD .................... 38
Additional Price Premium Commanded by an Improved BRD ..................... 39
Summary of Survey Findings (2) ............................. 40
Influence on a Purchasing Decision for a New BRD ......................... 41
Attractiveness of a New BRD from a Purchasing Perspective ...................... 42
Trends Related To Purchasing a New BRD & Related Consumables .................... 43
Openness to Consider Alternative BRD Purchasing Scenarios ..................... 44
Interest in Alternative Purchasing Strategies for BRD Replacement (1) ................... 45
Interest in Alternative Purchasing Strategies for BRD Replacement (2) ................... 46
2012 Capex Budget for BRDs (1) ................................ 47
2012 Capex Budget for BRDs (2) ................................ 48
Breakdown of Total Liquid Handling Capex Budget Today (2012) ...................... 49
Future Purchasing Interest in Different Vendor’s BRDs (1) ..................... 50
Future Purchasing Interest in Different Vendor’s BRDs (2) ..................... 51
Current & Future Interest in Vendor’s BRDs ............................ 52
2012 Annual Budget for BRD-Related Consumables (1) ......................... 53
BRD Instruments Global Market Estimate ........................... 54
BRD-Related Consumables Global Market Estimate ........................ 55
Unmet Needs in BRD Dispensing Today ............................. 56
Summary of Survey Findings (3) ............................. 57